Binary cooperative prodrug nanoparticles
WebFeb 6, 2024 · Our designed amphipathic prodrug that owns a long lipid chain and hydrophilic polyethylene glycol (PEG2k) in axial ligands can self-assemble into nanomicelles (PEG-OXA NPs) in water. Malvern spray analyzer was used to measure the particle size and size distribution of PEG-OXA NPs. WebApr 29, 2024 · A novel immunoregulatory prodrug micelle based on polyethylene glycol-derivatized an IDO-selective inhibitor of 1-methyltryptophan (1-MT), PEG-Fmoc-1-MT, was developed for inhibiting the IDO activity of the conversion of Trp to Kyn in tumor microenvironments. ... (2024) Binary cooperative prodrug nanoparticles improve …
Binary cooperative prodrug nanoparticles
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WebAug 13, 2024 · An on‐demand autophagy cascade amplification nanoparticle (ASN) is established to intelligently boost oxaliplatin (OXA)‐induced immunotherapy of cancer cells. Upon arrival at tumor site, ASN... WebApr 21, 2024 · Nanoparticle-based approaches have been explored, and a binary cooperative prodrug nanoparticle (BCPN) was designed to provide balance by …
WebProdrug nanoparticles and hydrogels can be used to deliver other therapeutic agents for combination chemotherapy or immunotherapy. Advancements in the development of nanomaterials have led to the … WebJul 15, 2024 · Immune adjuvant-DOX prodrug nanoparticles were constructed by the interaction of CpG and PEI-DOX prodrug. First, we conjugated PEI with DOX to build a …
WebBinary cooperative prodrug nanoparticles improve immunotherapy by synergistically modulating immune tumor microenvironment. B Feng, F Zhou, B Hou, D Wang, T Wang, Y Fu, Y Ma, H Yu, Y Li. Advanced materials 30 (38), 1803001. , 2024. WebMoreover, nanoparticles sensitivities play an important part in controlled drug release. Feng et al 60 demonstrated a tumor acidity and reduction microenvironment dual-activatable binary cooperative prodrug nanoparticle (BCPN) to deliver OXA and NLG919 (an IDO-1 inhibitor) for chemo-immunotherapy. The exposed OXA promoted tumor infiltration of ...
WebFeng et al. demonstrated that the tumor microenvironment can be modulated by designing the dual‐activatable (acidic and reducing) binary cooperative prodrug nanoparticle (BCPN), where amphiphilic …
WebDec 9, 2024 · Several features of nanoparticles, including great biocompatibility, low side-effect, prolonged half-life, favorable biodistribution, and controlled stimuli‐responsive release of therapeutic agents, make them promising candidates for immunotherapy. foam gun not foamingWebFeb 9, 2024 · Binary dimeric prodrug nanoparticles for self-boosted drug release and synergistic chemo-photodynamic therapy Binary dimeric prodrug nanoparticles for self … green willows cardiffWebBCPN is purely constructed from a tumor acidity and reduction dual-responsive oxaliplatin (OXA) prodrug for triggering immunogenic cell … green willows newportWebFeb 6, 2024 · Herein, a novel Pt (IV) prodrug of oxaliplatin (OXA) was synthesized and prepared as self-assembled micellar nanoparticles (PEG-OXA NPs). In vitro, PEG-OXA NPs rapidly released biologically... green willows funeral directors cardiffWebAug 18, 2024 · Despite promising nanoparticle-based codelivery approaches in therapeutics, the pathophysiological barriers of solid tumors are a hurdle for tumor accumulation and deep penetration of the drug-loaded nanoparticles. A light-inducible nanocargo (LINC) for immunotherapy is reported. green willow soapWebApr 23, 2024 · Functional nanomaterials offer great potential for steady codelivery of various drugs, especially small molecules, therapeutic peptides, and nucleic acids, thereby … foam gun for washing carsWebMay 1, 2024 · Since light has the advantages of noninvasiveness, simple controllability and high spatio-temporal selectivity, therapeutic agents that can be activated by light, particularly near-infrared (NIR)... green willows properties