Hierarchical gatekeeping procedure
WebMultiple comparisons; Stepwise procedure; Truncated tests. 1 Introduction Gatekeeping procedures have become popular in recent years as they provide a convenient way to handle logical relationships between multiple hierarchical objectives that clinical trials are often re-quired to address. Web10 de nov. de 2016 · In this paper, we introduce a novel Bonferroni based multiple testing procedure for testing hierarchically ordered families of hypotheses. The proposed …
Hierarchical gatekeeping procedure
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WebGatekeeping procedures are often used to address multiplicity issues in clinical tri- als with hierarchically ordered objectives, e.g., comparisons of multiple doses with WebHochberg procedure (Xi & Bretz 2024) and several gatekeeping procedures (Dmitrienko et al. 2003, 2008, Li et al. 2024). However, controlling the FWER is a very stringent criterion, especially as the numberof hypotheses increases. By controlling the probability of even a single type I error, the power of FWER-controlling
http://users.iems.northwestern.edu/~ajit/papers/42)%20General%20Gatekeeping.pdf WebFirst, we give an overview of fundamental theories for multiple testing, such as partition testing and closed testing procedure. We then describe how gatekeeping strategies …
Web1 de jan. de 2006 · Related gatekeeping procedures addressing the problem of comparing several doses with a control for multiple hierarchical endpoints were described, among others, by Dmitrienko et al. (2006), Liu ... WebThe parallel gatekeeping testing strategy provides an opportunity to assess secondary objectives when all or partial primary objectives are achieved. The current available gatekeeping procedure … Major objectives of a clinical trial are commonly stated in a hierarchical order as primary and secondary.
Web24 de fev. de 2006 · The proposed procedure accounts for the hierarchical structure of the testing problem; for example, it restricts testing of secondary endpoints to the doses for which the primary endpoint is significant. ... Gatekeeping procedures with clinical trial applications, Pharmaceutical Statistics, 10.1002/pst.291, 6, 3, ...
Web1 de jul. de 2012 · Gatekeeping Procedure is used in the situation when there are multiple endpoints and these multiple endpoints are grouped into different families. … philosophy and comedyWebFigure 1: Graphical visualization of the gatekeeping procedure with truncated Holm procedure as gatekeeper. a truncated Holm procedure that is used for testing four … philosophy and chaos theoryWebGuilbaud (2007) incorporated the retesting option into Bonferroni based gatekeeping pro-cedures by allowing the families to be retested in a reverse order by using procedures … philosophy and cognitive sciencehttp://archives.njit.edu/vol01/etd/2010s/2014/njit-etd2014-050/njit-etd2014-050.pdf philosophy and christmasWebA Gatekeeping Test in a Group Sequential Design 1 1. Introduction Gatekeeping procedures for testing multiple hierarchical objectives such as tests on multiple endpoints have been been studied by many authors in the last 15 years, see, e.g.,Dmitrienko and Tamhane(2007,2009). For the most part, these studies are restricted to xed sample … philosophy and climate changehttp://users.iems.northwestern.edu/~ajit/papers/40)%20Gatekeeping%20review07.pdf philosophy and counsellingWebA general method for building gatekeeping procedures, known as the mixture method, tends to be conservative in problems with several sequences of hypotheses. This article defines a modified mixture method and shows that this method provides a power advantage over the standard mixture method. philosophy and contemporary society