Irf4 binding motif

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August undefined, 2024

WebAug 25, 2024 · IRF4 is critical to full T cell activation, metabolic upregulation, and function but binds DNA weakly on its own and depends on interactions with other transcription … WebMar 1, 2015 · Motif analysis of the chicken ovalbumin upstream promoter-transcription factor II DNA-binding intervals revealed an enrichment in FOXO1 motifs . The role of IRF4 in the modulation of inflammation and immune response in differentiating HESCs remains to …

Dual Roles of PU.1 in the Expression of PD-L2: Direct …

Web(a) Motif analysis of IRF4-binding sites based on the 1,338 most significant peaks (P < 10−10); the 100-bp sequences centered on the binding summit were used for analysis; … how many super bowls has drew brees played

BATF–JUN is critical for IRF4-mediated transcription in T …

WebJun 21, 2013 · BATF leucine zipper motifs interact with interferon-regulatory factor 4 (IRF4) and IRF8 at AP-1–IRF consensus elements (AICEs). The discovery of the BATF–IRF … WebDec 16, 2013 · The transcription factor interferon regulatory factor-4 (IRF4) is expressed in B cells at most developmental stages. In antigen-activated B cells, IRF4 controls germinal … WebJan 7, 2003 · PU.1 is a hematopoiesis-specific ets family transcription factor expressed in myeloid and B cells (1, 2).PU.1 binds to DNA and recruits a transactivation partner, IFN regulatory factor 4 (IRF4) (), to an adjacent DNA sequence ().Phosphorylation of S148 in the PEST (proline, glutamine, serine, and threonine rich) domain of PU.1 is essential for strong … how many super bowls has drew brees won

Frontiers Suppression of FOXP3 expression by the AP-1 …

Entry - *601900 - INTERFERON REGULATORY FACTOR 4; IRF4

WebOct 10, 2024 · To investigate whether PDGF D has any biological functions independent of its ability to activate β-PDGFR possibly via the CUB domain, three arginine residues in the R 340 R 341 GR 343 motif within the GFD, known to be critical for its binding to β-PDGFR, were mutated to alanines (TM). 26 To purify recombinant GFD-D proteins, the CUB domain ... WebAug 13, 2024 · Interferon regulatory factor 4 (IRF4) is a lymphoid transcription factor and a key regulator in the development of various immune cells, including T and B cells. It is well-known that IRF4 controls numerous decision-making processes relating to B cell … how did trade affect the medieval periodWebDec 18, 2009 · Genome-wide ChIP-Seq mapping of STAT3- and IRF4-binding sites showed that most regions with IL-21-induced STAT3 binding also bound IRF4 in vivo and furthermore revealed that the noncanonical TTCnnnTAA GAS motif critical in Prdm1 was broadly used for STAT3 binding. how many super bowls has elway won

"WebIRF4, a member of the interferon regulatory factor (IRF) family, was previously shown to be restricted in the immune system and involved in the differentiation of immune cells. … " - Irf4 binding motif

Irf4 binding motif

National Center for Biotechnology Information

WebMay 23, 2013 · At higher concentrations, IRF4 binding shifted to interferon sequence response motifs; these enriched for genes involved in plasma cell differentiation. Our results support a model of “kinetic control” in which signaling-induced dynamics of IRF4 in activated B cells control their cell-fate outcomes. Graphical Abstract WebDec 17, 2024 · BATF and IRF4 bind to AP-1-IRF-composite element (AICE) motifs 37, 38, 39, 40, but how BATF and other AP-1 transcription factors regulate IRF4 activity in the eTreg transcriptional program is...

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WebJul 17, 2015 · The AICE motif directs assembly of IRF4 or IRF8 (601565) with BATF heterodimers and is also used in TH2, B, and dendritic cells. ... (164720) or Ap1 (165160) binding sites with Pu.1 (SPI1; 165170) or Batf (612476). At higher concentrations, Irf4 binding shifted to interferon sequence response elements, and these enriched for genes … WebAug 1, 2024 · PU.1 bound to the CNS3 probe even when the IRF4 binding motif was mutated , probably because the remaining Ets motif in the mutated probe can be bound with monomeric PU.1. To clarify whether PU.1 binds to CNS3 by itself in living cells, we evaluated the effect of IRF4 knockdown on the binding degree of PU.1 to the EICE in CNS3 by a ChIP …

WebApr 4, 2024 · IRF4 protects arteries against neointima formation by promoting the expression of KLF4 by directly binding to its promoter. We propose that the Irf4 locus functions as the "reader" of TCR signal strength, and in turn, concentration-dependent activity of Irf4 "writes" T helper fate choice. WebNational Center for Biotechnology Information

WebIRF4 is a negative regulator of TLRs and regulates the production of proinflammatory cytokines by macrophages in response to LPS and signals via complexes containing … WebMar 14, 2024 · The IRF4 protein acts like a switch that turns on and off some genes involved in the body’s response to infection. In patients with this mutation, the IRF4 protein does not work as it should. Guérin et al. suggest that Whipple’s disease may be caused by specific genetic mutations affecting the immune system in subjects infected by T. whipplei.

WebTo optimize motif analysis to distinguish sequence requirements of high-affinity versus a low-affinity AICEs, we needed to identify which motif(s) within a peak were functional for BATF/IRF4...

WebJan 20, 2024 · Abstract. Interferon regulatory factor 4 (IRF4) is a transcription factor (TF) and key regulator of immune cell development and function. We report a recurrent … how many super bowls has jared goff played inWebMar 19, 2024 · In addition, we analyzed the distribution of DNA binding motifs within ±3 kilobase pairs (kb) from the sites bound by both IRF4 and NF-κB (Figure 2F; supplemental Table 4). As expected, both IRF and NF-κB binding motifs were enriched at the center of transcription factor binding sites. how did toys r us startWebIRF4 IRF-4 is a member of the interferon regulatory factor (IRF) family of transcription factors, which were first identified as being involved in the expression of interferon-induced genes. From: The Immune Response, 2006 Related terms: CD4 IRF8 T Cells Plasma Cell Lymphoma Germinal Center Cellular Differentiation Phenotype B Cell Proteome how many super bowls has green bay wonWebSep 1, 2006 · The mammalian IRF family comprises nine members: IRF1, IRF2, IRF3, IRF4 (also known as LSIRF, PIP or ICSAT), IRF5, IRF6, IRF7, IRF8 (also known as ICSBP) and IRF9 (also known as ISGF3γ) 4, 5.... how many super bowls has emmitt smith wonWebFeb 4, 2024 · IRF4 plays important roles in controlling the stimulatory properties of DCs but the mechanisms and contexts by which these are deployed to regulate Th responses are less well understood ( Bajaña et al., 2012; Vander Lugt et al., 2014 ). how did trade help the colonies growWebApr 24, 2024 · The transcription factor (TF) interferon regulatory factor-4 (IRF4) promotes both germinal center (GC) reactions and plasma cell (PC) differentiation by binding to … how did trafalgar law lose his armWebFeb 26, 2024 · Interferon regulatory factor 4 (IRF4) is a key transcription factor (TF) in the regulation of immune cells, including B and T cells. It acts by binding DNA as both a homodimer and, in conjunction with other TFs, as a heterodimer. The choice of homo and heterodimeric/ DNA interactions is a critical a … how did trade begin in neolithic settlements