Phosphorylation of irf3 antibody

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August undefined, 2024

WebSTING agonist-28. STING Infection; STING agonist-28 (CF510) is a non-nucleotide small-molecule STING agonist.STING agonist-23 activates STING, increases phosphorylation of STING, TBK1 and IRF3.STING agonist-23 promotes the levels of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-5 in tumor cells.STING agonist-23 exhibits activity against SARS-CoV … WebOct 22, 2024 · IRF3 is a transcription factor that participated in type I IFN production, and its function is realized by transposition from the cytoplasm to the nucleus (Vandevenne et al., …

Control of IRF-3 activation by phosphorylation - PubMed

Web(C–F) Western blots of phosphorylated IRF3 and beta actin in HEK293-Null and HEK293-TLR3 cells at various time points following WNV infection or post-treatment with the TLR3 agonist poly I:C. Mock infected cells and cells treated with inactivated WNV are … WebPhospho-IRF-3 (Ser396) Antibody detects endogenous levels of IRF-3 only when phosphorylated at Ser396. This antibody does not cross-react with other family members at physiological conditions. Species Reactivity: Human. Species predicted to react based on … Highly specific and rigorously validated in-house, Phospho-IRF-3 (Ser396) (4D4G) … sonic hard seltzer locations

The innate sensor ZBP1-IRF3 axis regulates cell proliferation in ...

WebSep 25, 2015 · Viral infection activates the transcription factors NF-κB and IRF3, which contribute to the induction of type I interferons (IFNs) and cellular antiviral responses. Protein kinases play a critical role in various signaling pathways by … WebMar 21, 2024 · IRF3 (Interferon Regulatory Factor 3) is a Protein Coding gene. Diseases associated with IRF3 include Encephalopathy, Acute, Infection-Induced 7 and … WebJan 20, 2009 · In this study, we show that another kinase, c-Jun-NH2-terminal kinase (JNK), phosphorylates IRF3 on its N-terminal serine 173 residue, and TAK1 can stimulate IRF3 … small house open concept

The TAK1-JNK cascade is required for IRF3 function in the innate immune

Vinculin Mouse Monoclonal Antibody Affinity Biosciences LTD 亲 …

Web该IRF3 Polyclonal Antibody. This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha … WebJan 29, 2015 · Point mutations at IRF3’s positively charged surfaces abrogated IRF3 binding to MAVS and STING and subsequent IRF3 phosphorylation and activation. We … sonic hard seltzerWebNational Center for Biotechnology Information sonic hartshorne ok

"WebPhospho-IRF3 (Ser386) Antibody (PA5-78025) in WB Western Blot using Phospho-IRF3 (Ser386) Polyclonal Antibody ( Product # PA5-78025 ). Untreated (–) and treated (+) THP-1 whole cell extracts (30 µg) were separated by 10% SDS-PAGE, and the membrane was blotted with Phospho-IRF3 (Ser386) Polyclonal Antibody ( Product # PA5-78025) diluted … " - Phosphorylation of irf3 antibody

Phosphorylation of irf3 antibody

Phosphorylation of innate immune adaptor proteins MAVS, STING …

WebTBK1-dependent phosphorylation of IRF3 leads to its nuclear translocation and subsequent activation of transcriptional programs that ultimately lead to the production of inflammatory cytokines, ... Staining with a dsDNA-specific antibody showed that such treatment is sufficient to induce cytosolic accumulation of dsDNA (Fig 1J, ... WebUse Anti-phospho-IRF-3 (Ser396) Antibody (Rabbit Polyclonal Antibody) validated in WB to detect phospho-IRF-3 (Ser396) also known as Interferon regulatory factor 3. Anti-phospho …

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WebApr 11, 2024 · In the TLR4-TRIF-IRF3-type I IFN signaling cascade, phosphorylation of the TBK1 kinase is a key step 2. Phosphorylated-TBK1 (pTBK1) subsequently phosphorylates IRF3, which then translocates... WebKey features and details Rabbit polyclonal to IRF3 (phospho S396) Suitable for: WB Reacts with: Human Isotype: IgG You may also be interested in Primary Anti-IRF3 (phospho S386) antibody [EPR2346] - BSA and Azide free (ab182859) Protein Recombinant Human IRF3 protein (ab205216) Secondary Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

WebPrimary Anti-IRF3 (phospho S386) antibody [EPR2346] - BSA and Azide free (ab182859) Protein Recombinant Human IRF3 protein (ab205216) View more associated products Overview Product name Anti-IRF3 antibody … WebJan 24, 2016 · The IRF3 transcription factor is critical for the first line of defense against pathogens mainly through interferon β and antiviral gene expression. A detailed analysis …

WebWestern blot analysis of Phospho-IRF3 pSer385 using Phospho-IRF3 pSer385 polyclonal antibody (Product # PA5-36775) at a dilution of 1:500. Lane 1: Hela cell lysate treated with PMA (100nM, 15min), Lane 2: … WebIt is now well established that TBK1 is responsible for IRF3 phosphorylation in response to stimulation of several intracellular receptors that induce type-I interferons, including TLR3, …

WebMAP3K8 mediates the phosphorylation and repression of IRF3 homodimers to promote greater transcriptional activity through utilization ... More The induction of the intrinsic antiviral defense in mammals relies on the accumulation of foreign genetic material.

WebOverview Product name Anti-IRF3 (phospho S396) antibody See all IRF3 primary antibodies Description Rabbit polyclonal to IRF3 (phospho S396) Host species Rabbit Tested … sonic harlingenWeb研究背景. P18206_VINC_HUMAN. 功能: Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. sonic hatchback 2012 interiorWebPhosphorylation of IRF3 occurs at a cluster of serine and threonine residues in the carboxy-terminus between residues 385 and 405. This leads to an association with the p300/CBP coactivator and stimulation of … small house on stiltsWebAnti-IRF3 antibody [IRF35I218] (ab50772) Datasheet Reviews ( 3) Q&A (4) References (9) Key features and details Mouse monoclonal [IRF35I218] to IRF3 Suitable for: ICC/IF, WB, Flow Cyt Reacts with: Human Isotype: IgG1 You may also be interested in Primary Alexa Fluor® 488 Anti-PSMA antibody [GCP05] (ab187570) sonic hartselleWebMar 23, 2001 · Although the broad-spectrum kinase inhibitor staurosporine potently blocked IRF3 and -7 phosphorylation, inhibitors for protein kinase C, protein kinase A, MEK, SAPK, … small house on landWebSep 1, 2024 · Published findings and our results show that IRF3 is a transcription factor under the tight control by phosphorylation-dependent post-translational modification. … small house on the lakeWebMar 8, 2024 · The dimerization and phosphorylation of IRF3 as well as the phosphorylation of TBK1 are hallmarks of the cytosolic DNA-triggered signaling. These processes were apparently inhibited in Rnf185 knockdown L929 cells, when stimulating cells with HT-DNA (Figs 2A and S4A ). small house on slope