Shoc2蛋白

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August undefined, 2024

WebSrc Homolgy-2磷酸酶(SHP2)是PTPN11基因所编码的非受体蛋白酪氨酸磷酸酶，其促进多种细胞功能，包括增殖、分化、细胞周期维持和迁移。 SHP2牵涉在经由Ras-有丝分裂原-激活的蛋白激酶、JAK–STAT或磷酸肌醇3-激酶-AKT途径的信号传导中。 WebSHOC2 has been shown to interact with the catalytic phosphatase subunit PP1C(PMID 16630891) and MRAS as well as canonical RAS isoforms (H/K/NRAS)(PMID 35768504, 35831509, 35830882). The ternary complex SHOC2-RAS-PP1C functions to dephosphorylate an inhibitory phosphorylation site ('S259') on RAF family proteins to enable MAPK …

研究揭示SHOC2调控RAS信号的结构基础—小柯机器人—科 …

Web10 May 2024 · SHOC2 acts as a strong synthetic lethal interactor with MEK inhibitors in multiple KRAS cancer cell lines. SHOC2 forms a heterotrimeric complex with MRAS and … Web13 Jul 2024 · The researchers found that when they deleted the SHOC2 gene or decreased its expression, the MEK inhibitors were highly effective at eliminating cancer cells, revealing SHOC2 as a culprit in resistance to MEK inhibitors. Protein puzzle. The team decided to further study SHOC2 as a potential target, which included solving its structure. caged acoustic guitar forum

SHOC2 - Wikipedia

Web21 Mar 2024 · SHOC2 (SHOC2 Leucine Rich Repeat Scaffold Protein) is a Protein Coding gene. Diseases associated with SHOC2 include Noonan Syndrome-Like Disorder With … WebThe potential SHOC2 inhibitor celastrol phenocopied SHOC2 depletion. In addition, we confirmed that SHOC2 expression levels were important for the sensitivity to EGFR-TKIs in … cmt breaking news

Structure of the SHOC2–MRAS–PP1C complex provides insights …

Structure of the SHOC2–MRAS–PP1C complex provides ... - bioRxiv

Web7 Aug 2024 · Inhibiting SHOC2, the researchers hypothesised, could therefore be an alternative way to indirectly inhibit RAF and dial down ERK activity. To test this idea, Jones et al. genetically modified mice to eliminate SHOC2. Excitingly, this suppressed tumour development and enhanced survival in a mouse model of mutant RAS lung cancer. … Web采集先证者及其父母外周血，提取基因组dna行全外显子组测序，结果显示，先证者shoc2基因2号外显子存在c.4a>g错义突变，导致第2号氨基酸由丝氨酸变为甘氨酸（p.s2g），患儿父母未检出该突变。结合临床表型与基因突变，确诊为努南样综合征伴生长期毛发松动。 caged acabouWebSHOC2. （SHOC2 leucine rich repeat scaffold protein）. 这个基因编码一种几乎完全由富含亮氨酸重复序列组成的蛋白质，这是一个与蛋白质相互作用有关的结构域在RAS/ERK … caged am

"Webshoc2 是一种包含多个亮氨酸富集串联重复序列的支架蛋白，同时也是生长因子依赖性 mapk/erk 信号转导的一个上游正调节分子。研究表明，SHOC2 与 PP1 磷酸酶和 M-Ras 的 … " - Shoc2蛋白

Shoc2蛋白

New protein complex structure reveals possible ways to target key …

WebA key phosphatase that mediates this dephosphorylation step is a heterotrimeric complex composed of MRAS, SHOC2, and protein phosphatase 1 (PP1) ().SHOC2 is a ubiquitously expressed protein composed almost exclusively of leucine-rich repeats (LRRs) that was originally identified in Caenorhabditis elegans as a positive modulator of the ERK pathway … Web8 Jul 2024 · The authors identified a heterozygous mutation (S2G; 602775.0001) in the SHOC2 gene in 4 unrelated individuals. They then analyzed the SHOC2 gene in a cohort of …

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Web20 Jun 2001 · Function. Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS … Web3 Oct 2024 · This is achieved by PP1, whose specificity for RAF is conferred by the dual action of the scaffold protein SHOC2 and a second small GTPase, M-RAS. Four new structures, three published in Nature ...

Web7 Aug 2024 · This dephosphorylation relies on a multi-subunit phosphatase, known as the SHOC2 phosphatase complex. Inhibiting SHOC2, the researchers hypothesised, could … WebLeucine-rich repeat (LRR) protein SHOC-2 is a protein that in humans is encoded by the SHOC2 gene. The best-studied role of SHOC2 is in modulating signals of the extracellular …

WebHeat shock proteins are divided into several classes, they are found in every living organism. As well as being constitutively expressed regardless of circumstances, Heat shock … WebPubMed

WebPPP2R1B 蛋白质磷酸酶2调节亚基1B抗体 0.2ml PPP2R3A 蛋白质磷酸酶2调节亚基3A抗体 0.2ml SHOC2/Sur8 富含亮氨酸重复蛋白SHOC2抗体 0.2ml RAMP/CDT2 维甲酸调节核基质相关蛋白 0.2ml MTMR8 肌管素相关蛋白8抗体 0.2ml NIFK KI67相互作用蛋白抗体 0.2ml

Web10 May 2024 · SHOC2 acts as a strong synthetic lethal interactor with MEK inhibitors in multiple KRAS cancer cell lines. SHOC2 forms a heterotrimeric complex with MRAS and PP1C that is essential for regulating RAF and MAPK-pathway activation by dephosphorylating a specific phosphoserine on RAF kinases. Here we present the high … caged and dangerousWeb10 Jun 2024 · SHOC2 inhibition perturbs tumour growth in lung cancer models. To study the in vivo role of SHOC2 we have developed two mouse models of SHOC2 inactivation using Knock-out (KO) or Knock-in (KI ... caged actressWeb27 Jul 2024 · Based on a systems biology approach that identified SHOC2 as a candidate gene, Cordeddu et al. (2009) sequenced SHOC2 coding exons in a Noonan syndrome cohort that included 96 individuals who were negative for mutations in known disease genes and identified a heterozygous mutation (S2G; 602775.0001) in 4 unrelated individuals.They … caged and lockedWeb10 Jun 2024 · The MRAS-SHOC2-PP1 (SHOC2 phosphatase) complex plays a key role in RAF-ERK pathway activation by dephosphorylating a critical inhibitory site on RAF kinases. cmt broadcast scheduleWeb5 Nov 2024 · Studies over the past decade have uncovered the critical role of the Shoc2 scaffold in the transmission of signals through the core ERK1/2 cascade (Jang et al., 2024).These studies convincingly demonstrated that this seemingly auxiliary component of the ERK1/2 signaling network is an indispensable regulator of the ERK1/2 pathway, as its … caged and enraged ac odysseyWeb29 Jun 2024 · shoc2是一个重要的支架蛋白，它与pp1c和ras一起参与raf ntps11的去磷酸化，但shoc2的结构和推定的shoc2-pp1c-ras复合物的结构仍然未知。 caged angel bandWebWhat Heat Shock Proteins do？. HSPs help to maintain homeostasis and stability of cellular proteins in many ways, they often work together to perform a combination of events.With some functions not yet understood, it is known that many HSPs have multiple roles. 热休克蛋白有助于以多种方式维持细胞蛋白的稳态和稳定性 ... caged agosto